Alan Cumming as Joe Therrian

Jennifer Jason Leigh as Sally Nash Therrian

John Benjamin Hickey as Jerry Adams

Parker Posey as Judy Adams

Phoebe Cates as Sophia Gold

Kevin Kline as Cal Gold

Owen Kline as Jack Gold

Greta Kline as Evie Gold

Denis O'Hare as Ryan Rose

Mina Badie as Monica Rose

Jane Adams as Clair Forsyth

John C. Reilly as Mac Forsyth

Jennifer Beals as Gina Taylor

Matt Malloy as Sanford Jewison

Mary Lynn Rajskub as Mary-Lynn

Michael Panes as Levi Panes

Gwyneth Paltrow as Skye Davidson

Blair Tefkin as Astrid

Karen Kilgariff as Karen

Molly Bryant as Party Guest

Michael G. Carroll as Party Guest

Craig Chester as Party Guest

Christopher Lawrence as Party Guest

Jessica Queller as Party Guest

JR Reed as Party Guest

Steven Freedman as Yoga Instructor

Norizzela Monterroso as America

Clara Demedrano as Rosa

Sadie Frost as Lucy - Joe's Sister (voice) (uncredited)

Matt McGrath as Jeffrey (uncredited)