David Mattey as Toxic Avenger / Noxious Offender

Debbie Rochon as Ms. Weiner

Clyde Lewis as Toxie (voice)

Heidi Sjursen as Sarah / Claire

Ron Jeremy as Mayor Goldberg

Tom Fulp as Painter

Paul Kyrmse as Sgt. Kabukiman / Evil Kabukiman

Stan Lee as Prologue / Epilogue Narrator

Joe Fleishaker as Chester / Lardass

Dan Snow as Sgt. Kazinski

Michael Budinger as Tito

Lisa Terezakis as Sweetie Honey

Barry Brisco as Pompey

Corey Feldman as Sarah's Gynecologist

Trent Haaga as Tex Diaper

Mark Torgl as Evil Melvin

Rick Collins as Amortville Police Chief

Mitch Cohen as Lucifer

Lisa Gaye as Abortion Counselor

James Gunn as Dr. Flem Hocking

Al Goldstein as Press Secretary

Taylor Mead as Award Presenter

Yaniv Sharon as Rex Diaper

Will Keenan as Man Hit by Car

Melissa Bacelar as Dr. Hocking's Nurse

Jasi Cotton Lanier as Wet Lesbian

Lemmy Kilmister as Good Lemmy / Bad Lemmy

Julie Strain as Herself (Facelift Death)

Kevin Eastman as Himself (Breast Smoosh Death)

Tiffany Shepis as Beautiful Interpretative Dancer

Eli Roth as Beautiful Young Boy

Hugh Hefner as President of the United States

Charlotte Kaufman as Tromaville / Amortville Citizen

Lloyd Kaufman as Man in Public Service Announcement

Neriah Davis as Glamorous Gyno-American

Devin DeVasquez as Glamorous Gyno-American

Taimie Hannum as Glamorous Gyno-American

Masuimi Max as Glamorous Gyno-American

Doria Rone as Glamorous Gyno-American

Petra Verkaik as Glamorous Gyno-American

Hank the Angry Drunken Dwarf as God

Celeste Octavia as Glamorous Gyno-American / Naked Nurse (as Celeste Octavian)

Tromelissa Saytar as Lesbian Art Student

Terri Firmer as Wet Lesbian / Topless Deaf Translator

Bella Compagna as Diaper Mafia Temptress

Brandi Brandt as Glamorous Gyno-American

Randy Sklar as Randy Diaz

Jason Sklar as Jason Gonzalez

Crystal McCloud as Nurse

Joe James as Tromaville Nazi #2

Matthew Goldpaugh as Tromaville Nazi - Angry Tromaville Citizen- Amortvillain