Ron Fazio as The Toxic Avenger / Apocalypse Inc. Executive

John Altamura as The Toxic Avenger

Phoebe Legere as Claire

Rick Collins as Apocalypse Inc. Chairman

Rikiya Yasuoka as Big Mac

Tsutomu Sekine as Announcer

Mayako Katsuragi as Masami

Shinoburyû as Shockikuyama

Lisa Gaye as Malfaire

Jessica Dublin as Mrs. Junko

Jack Cooper as Mr. Junko

Erika Schickel as Psychiatrist

Karen King as Bad Girl

Melissa Osborne as Bad Girl

Helen Wheels as Bad Girl

Bonnie Garvin as Bad Girl

Michael Jai White as Apocalypse Inc. Executive

Joe Fleishaker as Apocalypse Inc. Executive

William Decker as Apocalypse Inc. Executive

Dan Snow as Cigarface

Andrew Wolk as Pus Man

Eric Alan as Homeless Couple

William E. Benson as Father O'Reilly

Elliot Weiss as Dog Face

Arthur M. Jolly as Blind Choir Singer

Charlotte Kaufman as Blind Baby

Lily Hayes Kaufman as Toxic Child

Lisbeth Kaufman as Toxic Child

Patricia Kaufman as Diaper Changer

Jeffrey W. Sass as Good Person of Tromaville

Harry Williams Jr. as Good Person of Tromaville

David Greenspan as Good Person of Tromaville

Kei Nakata as Sumo Wrestler

Lloyd Kaufman as Sumo Wrestler / Fish Salesman (voice)

Go Nagai as Tsukudani Expert

Paul Borghese as Lou Sipher (uncredited)

Scott Leva as The Dark Rider (uncredited)

Zeeko Uchiyama as Person at Odaiba Beach

Maya Shiraki as Chain-Sickle Girl