Vincent Martella as Phineas Flynn (voice)

Thomas Brodie-Sangster as Ferb Fletcher (voice)

Ashley Tisdale as Candace Flynn (voice)

Dee Bradley Baker as Perry the Platypus (voice)

Dan Povenmire as Dr. Heinz Doofenshmirtz (voice) / Additional Voices

Maulik Pancholy as Baljeet Tjinder (voice)

Bobby Gaylor as Buford Van Stomm (voice)

Alyson Stoner as Isabella Garcia-Shapiro (voice)

Travis Willingham as Thor (voice)

Adrian Pasdar as Tony Stark / Iron Man (voice)

Drake Bell as Peter Parker / Spider-Man (voice)

Fred Tatasciore as Hulk (voice)

Liam O'Brien as Red Skull (voice)

Charlie Adler as M.O.D.O.K. (voice)

Danny Trejo as Venom (voice)

Peter Stormare as Whiplash (voice)

Caroline Rhea as Linda Flynn-Fletcher (voice)

Richard O'Brien as Lawrence Fletcher (voice)

Chi McBride as Nick Fury (voice)

Jeff 'Swampy' Marsh as Francis Major Monogram / Gordon Gutsofanemu / Additional Voices

Tyler Alexander Mann as Carl (voice)

John Viener as Norm (voice)

Stan Lee as NY Hotdog Vendor / Narrator (voice)

Jack McBrayer as Irving DuBois (voice)

Kelly Hu as Japanese Announcer / Additional voices

Allie Mac Kay as Little Old Lady