Dee Bradley Baker as Tippy Toe / Lockjaw (voice)

Chloe Bennet as Daisy Johnson / Quake (voice)

Dove Cameron as Gwen Stacy / Ghost-Spider (voice)

Skai Jackson as Gloria Grant

Kathreen Khavari as Kamala Khan / Ms. Marvel (voice)

Kamil McFadden as Patriot / Rayshaun Lucas (voice)

Bennett Abara as Sheath (voice)

Tyler Posey as Inferno / Dante Pertuz / Newspaper Man (voice)

Cierra Ramirez as America Chavez (voice)

Roger Craig Smith as Captain America / Doreen's Dad / Karl

Booboo Stewart as Exile / Victor Kohl (voice)

Tara Strong as Mary Jane Watson / Automated Voice (voice)

Milana Vayntrub as Squirrel Girl / Doreen Green (voice)

Steven Weber as Captain Stacy / Security Guard (voice)