Julianne Moore as Alice Howland

Kate Bosworth as Anna Howland-Jones

Shane McRae as Charlie Howland-Jones

Hunter Parrish as Tom Howland

Alec Baldwin as John Howland

Seth Gilliam as Frederic Johnson

Kristen Stewart as Lydia Howland

Stephen Kunken as Dr. Benjamin

Erin Darke as Jenny

Daniel Gerroll as Eric Wellman

Quincy Tyler Bernstine as Nursing Home Administrator

Maxine Prescott as Nursing Home Resident

Orlagh Cassidy as Primary Care Doctor

Rosa Arredondo as Convention Facilitator

Zillah Glory as Masha (Three Sisters)

Caridad Montanez as Elena

Cal Freundlich as Young Musician

Charlotte Robson as Young Musician

Jean Burns as Olga (Three Sisters) (uncredited)

José Báez as Head Waiter (uncredited)

Victoria Cartagena as Prof. Hooper (uncredited)

Jeannette Gould as Alzheimer's Patient (uncredited)

Takako Haywood as Alzheimer's Conference Attendee (uncredited)

Samantha Kelly as TV Reporter (uncredited)

Diane Kimbrell as Alzheimer's Patient (uncredited)

Cat Lynch as Pinkberry Worker (uncredited)

Joanne Perica as Crying Woman (uncredited)

Jamie Lee Petronis as Pinkberry Worker (uncredited)

Nancy Ellen Shore as Nurse (uncredited)

Eha Urbsalu as Alice's Mother (uncredited)