Cara Buono as Joanne

Isaach de Bankolé as Abraham

David Lansbury as Brian

Quinn Shephard as Linda

Robert Peters as Steve

Melissa Leo as Miriam

Paul Lazar as Larry

Helen Hanft as Shirley

Jimmy Gary Jr. as Sam

Rony Clanton as Frank

Sharon Wilkins as Jill

Joel de la Fuente as Alien

Robert Downey Sr. as Baker

Marcia Jean Kurtz as Brian's Mom

Larry Block as Brian's Dad

Lori Tan Chinn as Mrs. Kim

Jay Oakerson as Big Lab Assistant

Gregory Korostishevsky as Small Lab Assistant

Kristen Schaal as Information Librarian

Peter Bartlett as Curator

Laura Esterman as Psychiatrist

Susham Bedi as Vegetarian

Ed Wheeler as Guard

Jonah Meyerson as Henry

Richard M. Davidson as Doctor

David Smilow as Science Reporter

Michael Clinton as Farmer

Joseph McKenna as Confessor

Lori Braverman as Woman Gambler

Alberto Vasquez as Jerry

Tyagi Schwartz as Rosselli

Johann Carlo as Frieda

Ethan Crough as Jack

Kola Ogundiran as Peter

Sean Sutherland as Tourist

Peri Smilow as News Reporter

Dwandra Nickole as Admissions Person

Traci Parks as Conservator