Ryan Reynolds as Wade Wilson / Deadpool

Morena Baccarin as Vanessa

Ed Skrein as Ajax

T.J. Miller as Weasel

Gina Carano as Angel Dust

Leslie Uggams as Blind Al

Brianna Hildebrand as Negasonic Teenage Warhead

Stefan Kapičić as Colossus (voice)

Karan Soni as Dopinder

Randal Reeder as Buck

Michael Benyaer as Warlord

Style Dayne as Jeremy (Pizza Guy)

Kyle Cassie as Gavin Merchant

Taylor Hickson as Meghan Orlovsky

Ayzee as Teen Girl #1

Naika Toussaint as Teen Girl #2

Isaac C. Singleton, Jr. as Boothe

Justyn Shippelt as Arcade Ticket Taker

Donna Yamamoto as Oncologist

Jed Rees as Recruiter

Hugh Scott as David Cunningham

Cindy Piper as Chinatown Merchant

Em Haine as Whisper Girlfriend

Aatash Amir as Whisper Boyfriend

Chad Riley as Pool Hall Goon

Paul Belsito as Fight Club Boss

Darcey Johnson as Garbage Truck Driver

Kyle Rideout as Super Soldier #1

Jason William Day as Super Soldier #2

Stan Lee as Strip Club DJ

Benjamin Wilkinson as No5 Orange Manager

Rachel Sheen as Strip Club Worker

Paul Lazenby as Flight Deck Guard

Rob Hayter as Bob

Andre Tricoteux as On-Set Colossus (uncredited)

Victoria De Mare as Stripper (uncredited)

Heather Ashley Chase as Stripclub Pole Performer (uncredited)

Kayla Adams as Waitress Kelly (uncredited)

Olesia Shewchuk as Guadalajaran Mother (uncredited)

Fabiola Colmenero as Guadalajaran Nurse (uncredited)

Matthew Hoglie as Strip Club Patron (uncredited)

Bradley Archie as Hospital Doctor (uncredited)

Colleen Bradford as Bar Patron (uncredited)

John Dryden as Thug #2 (uncredited)

Jesse Michael Fullington as Guy in Strip Club (uncredited)

David Hardware as Strip Club Spectator (uncredited)

Tony Chris Kazoleas as Fight Club Spectator (uncredited)

Greg LaSalle as Colossus (Facial Performance) (uncredited)

Rob Liefeld as Liefeld (uncredited)

David Longworth as Elderly Man (uncredited)

Michael Neumeyer as Soldier #1 (uncredited)

Justin Pumillo as Backgound Extra (uncredited)

Sean Quan as Ten-year-old Boy (uncredited)

Anthony J. Sacco as Thug #3 (uncredited)

David Santana as Biker in Strip Club (uncredited)

Bronwyne Sloley as Fight Club Spectator (uncredited)

Dan Zachary as Biker (uncredited)