Matthew Modine as Dr. Don Francis

Alan Alda as Dr. Robert Gallo

Patrick Bauchau as Dr. Luc Montagnier

Nathalie Baye as Dr. Françoise Barre

Christian Clemenson as Dr. Dale Lawrence

David Clennon as Mr. Johnstone

Phil Collins as Eddi Papasano

Bud Cort as Antique Shop Owner

Alex Courtney as Dr. Mika Popovic

David Dukes as Dr. Mervyn Silverman

Richard Gere as The Choreographer

David Marshall Grant as Dennis Seeley

Ronald Guttman as Dr. Jean-Claude Chermann

Glenne Headly as Dr. Mary Guinan

Anjelica Huston as Dr. Betsy Reisz

Ken Jenkins as Dr. Dennis Donohue

Richard Jenkins as Dr. Marc Conant

Tchéky Karyo as Dr. Willy Rozenbaum

Swoosie Kurtz as Mrs. Johnstone

Jack Laufer as Mrs. Johnstone

Donal Logue as Bobbi Campbell

Steve Martin as The Brother

Richard Masur as William W. Darrow, PhD

Dakin Matthews as Congressman Phil Burton

Ian McKellen as Bill Kraus

Peter McRobbie as Dr. Max Essex

Lawrence Monoson as Chip

Jeffrey Nordling as Gaetan Dugas

Saul Rubinek as Dr. Jim Curran

Charles Martin Smith as Dr. Harold Jaffe

Stephen Spinella as Brandy Alexander

Lily Tomlin as Dr. Selma Dritz

BD Wong as Kico Govantes

Walter Addison as Blood Bank Executive

Jill Andre as Red Cross Spokesperson

Alan Barry as Hemophiliac Patient

Neal Benari as Dr. Tom Spira

David Dean Bottrell as Man #3

Rico Bueno as Bellevue Hospital Patient

Bill Carmichael as Delivery Man

Christopher Carroll as Dr. Aaron Kellner

Reg E. Cathey as Staff Doctor #2

John Del Regno as Man in Grand Central

John Durbin as 6th Man

Mogens Eckert as Chief Executive (Copenhagen)

Carey Eidel as Tennis Player

Robert Briscoe Evans as 2nd Reporter

Richard Fancy as Dr. Michael Gottlieb

Keythe Farley as Lab Technician

Christopher John Fields as Lawyer

Dave Florek as Doughnut Shop Counterman

Niki Guluchi as Sudanese Girl

Yasmine Golchan as Dr. Françoise Brun-Vezinet

Patrick Gorman as Charles Dauget

James Greene as Dr. Alvin Freedman-Kien

Jeff Hayenga as Dr. Bruce Voeller

Daniel Henning as Blaine

Ike Ikediashi as Sudanese Boy

Laura Innes as Hemophiliac Representative

Laura James as Margaret Heckler

Michael Kearns as Cleve

Erasor Kemie as Sudanese Student

Jack Kenny as San Francisco Activist

Thomas Kopache as Blood Bank Executive

Clyde Kusatsu as Blood Bank Executive

Frank Li'Bay as Desk Clerk

Rob LaBelle as Gay Rights Activist

Neal Lerner as 1st Man

René Le Vant as Blood Bank Executive

Anthony Lucero as Mailroom Man

James Mastrantonio as 8th Man

Jon Matthews as Greg

Rosemary Murphy as Blood Bank Executive

Susanne Olsen as Intern (Copenhagen)

Angela Paton as Woman in Denver

Sierra Pecheur as Female Reporter

Miguel Pérez as Reporter

Martin Raymond as 4th Man

Jeremy Regan as Ticket Seller

Robert Martin Robinson as Chief Administrator (French)

Valeri Ross as Jim's Secretary

Hildur Ruriks as Female Danish 2nd Executive

Tom Schanley as Waiter

Sean Whitesell as Country Club Attendant

Michael Winters as Middle-Aged Man

William Wintersole as Dr. Paul Florino

Lenny Wolpe as Dr. Joseph Bove

Geoffrey Lower as Dr. David Simpson

Richard Marcus as Reporter (uncredited)