Jack Nicholson as Melvin Udall

Helen Hunt as Carol Connelly

Greg Kinnear as Simon Bishop

Cuba Gooding Jr. as Frank Sachs

Shirley Knight as Beverly Connelly

Jesse James as Spencer Connelly

Yeardley Smith as Jackie Simpson

Lupe Ontiveros as Nora Manning

Skeet Ulrich as Vincent Lopiano

Harold Ramis as Dr. Bettes

Lawrence Kasdan as Dr. Green

Bibi Osterwald as Neighbor Woman

Ross Bleckner as Carl

Bernadette Balagtas as Caterer

Jaffe Cohen as Partygoer

Laurie Kilpatrick as Partygoer

Alice Vaughn as Partygoer

Brian Doyle-Murray as Handyman

Kristi Zea as Mother at Table

Annie Maginnis Tippe as Daughter at Table

Patricia Childress as Cafe 24 Waitress

Rebekah Johnson as Cafe 24 Waitress

Missi Pyle as Cafe 24 Waitress

Leslie Stefanson as Cafe 24 Waitress

Tara Subkoff as Cafe 24 Waitress

Shane Black as Cafe 24 Manager

Peter Jacobson as Man at Table

Lisa Edelstein as Woman at Table

Stan Bly as Cafe 24 Customer

Randall Batinkoff as Carol's Date

Jamie Kennedy as Street Hustler

Justin Herwick as Street Hustler

Maya Rudolph as Policewoman

John F. O'Donohue as Detective Ray

Dr. David A. Kipper as Hospital Doctor

Mary Elizabeth Still as Nurse Receptionist

Chloe Brooks as Child at Cafe 24

Cooper Brooks as Child at Cafe 24

Sharon L. Alexander as Female Passerby

Holly Denys as Female Passerby

Alison Rose as Psychiatric Patient

Kathryn Morris as Psychiatric Patient

Wood Harris as Cafe 24 Busboy

Linda Gehringer as Publisher

Julie Benz as Receptionist

Antonia Jones as Nurse

Kaitlin Hopkins as Woman in Lobby

Jimmy Workman as Sean from the Bakery

Danielle Spencer as Veterinarian

Todd Solondz as Man on Bus

Tom McGowan as Maitre'd

Danielle Brisebois as Singer

Matt Malloy as Men's Store Salesman

Paul Greenberg as Bar Waiter

Kirk Ringberg as Food Waiter

Dave Hawthorne as Bartender

Dunya Djordjevic as Art Dealer (uncredited)

Alex Ballar as Flower Store Customer (uncredited)

Jason Thomas Campbell as Valet (uncredited)

Amy Anzel as Ballet Dancer (uncredited)

Eliza Harris as Ballet Dancer (uncredited)

Eddie L. Fauria as NYC Transit Cop (uncredited)

Frank Slaten as Miffed Party Goer (uncredited)

Laura Mayes Byrnes as Restaurant Patron (uncredited)

Oriana Nicole Tavoularis as Restaurant Patron (uncredited)

Roger Ferreira as Restaurant Patron (uncredited)

Bronwyn Cornelius as Bartender (uncredited)

Maurice LaMarche as Fred Bishop - Simon's Dad on Phone (voice) (uncredited)

Ava Lee Scott as New Yorker