Jack Nicholson as Harry Sanborn

Diane Keaton as Erica Barry

Keanu Reeves as Dr. Julian Mercer

Frances McDormand as Zoe

Amanda Peet as Marin

Jon Favreau as Leo

Paul Michael Glaser as Dave

Rachel Ticotin as Dr. Martinez

Peter Spears as Danny Benjamin

Patrick Fischler as Stage Manager

KaDee Strickland as Kristen

Lorna Scott as Mrs. Gimble

T.J. Thyne as Waiter

Paige Butcher as Beauty

Tanya Sweet as Beauty

Kristine Szabo as Beauty

Daniella van Graas as Beauty

Tamara Spoelder as Beauty

Sonja Francis as Beauty

Vanessa Trump as Beauty

Kathy Tong as Beauty

Marjie Gum as French Girl in Market

Jennifer Siebel Newsom as Younger Woman in Market

Robert Frank Telfer as Older Man in Market

Beatrice Quinn as Lady in Market

Connie Sawyer as Lady in Market

Lorraine Nicholson as Young Girl in Market

Ara Anton as Paramedic

Melette Le Blanc-Cabot as Hamptons Nurse

Suzanne Dizon as Hamptons Nurse

Audrey Wasilewski as Hamptons Nurse

Roxanne Beckford as Hamptons Nurse

Robin Pearson Rose as Hamptons Nurse

Tania Deighton as Harry's Assistant

Nicki Norris as Harry's Assistant

Tayrene Mugridge as Harry's Dinner Date

Elayn J. Taylor as NYC Nurse

Conroe Brooks as NYC Nurse

Taylor Block as Young Patient

Melissa Keller as Party Guest

Genelle Frenoy as Party Guest

Nichole Hiltz as Harry's Lunch Date

Leslie Upson as Broadway Actress

Lewis Dauber as Actor in Cast Photo

Julia Sanford as Actor in Cast Photo

Jamie Bullock as Actor in Cast Photo

Michelle Fabiano as Harry's Old Flame

Catherine McGoohan as Harry's Old Flame

Blaine Allen as Harry's Old Flame

Julia Rose as Harry's Old Flame

Joan Adelle Nelson as Harry's Old Flame

Cindy Joseph as Harry's Old Flame

Alexandra Neil as Harry's Old Flame

Susan Misner as Harry's Old Flame

Sean Smith as Maitre'd

María Esquivel as Hostess

Madelyn Kennedy as Marin's Baby

Raney Kennedy as Marin's Baby

Kevin Watson as Self (uncredited)

Cass Asher as ER Patient (uncredited)

Scott Alan Taylor as Emergency Room Nurse (uncredited)

Deborah Daulton-Morton as Christie's Auction Goer (uncredited)

Matthew McCullough as Christie's Auction Goer (uncredited)

Lynne Langdon as Market Shopper (uncredited)

John H. Tobin as Limo Driver (uncredited)

Jennifer Montague as Party Guest (uncredited)

Adele Jacques as Ritz Concierge (uncredited)

André Crudo as Man in Hotel Lobby (uncredited)

James Hunter as Cab Driver (uncredited)

Shashi Balooja as Bartender (uncredited)

Dean Wood as Bartender (uncredited)

Bev Reese as Girl in Bar (uncredited)

Larry Lane as Karaoke Twin (uncredited)

John Dalton as Waiter (uncredited)

Ayse Eldek as Restaurant Patron (uncredited)

Alan Charof as Beaten Man (uncredited)

Troy Christian as Dancer (uncredited)

Elisabeth Granli as Girl (uncredited)