Robert Downey Jr. as Dan Dark

Robin Wright as Nicola, Nina, Blonde

Mel Gibson as Dr. Gibbon

Jeremy Northam as Mark Binney

Katie Holmes as Nurse Mills

Adrien Brody as First Hood

Jon Polito as Second Hood

Carla Gugino as Betty Dark / Hooker

Alfre Woodard as Chief of Staff

Amy Aquino as Nurse Nozhki

David Dorfman as Young Dan Dark

Saul Rubinek as Skin Specialist

Andy Umberger as Mr. Dark