Isabella Rossellini as Dorothy Vallens

Kyle MacLachlan as Jeffrey Beaumont

Dennis Hopper as Frank Booth

Laura Dern as Sandy Williams

Hope Lange as Mrs. Williams

Dean Stockwell as Ben

George Dickerson as Detective Williams

Priscilla Pointer as Mrs. Beaumont

Frances Bay as Aunt Barbara

Jack Harvey as Mr. Beaumont

Ken Stovitz as Mike

Brad Dourif as Raymond

Jack Nance as Paul

J. Michael Hunter as Hunter

Dick Green as Don Vallens

Fred Pickler as Yellow Man

Philip Markert as Dr. Gynde

Leonard Watkins as Double Ed

Moses Gibson as Double Ed

Selden Smith as Nurse Cindy

Peter Carew as Coroner

Jon Jon Snipes as Little Donny

Angelo Badalamenti as Piano Player

Jean-Pierre Viale as Master of Ceremonies

Donald Moore as Desk Sergeant

A. Michelle Depland as Party Girl

Michelle Sasser as Party Girl

Katie Reid as Party Girl