John Barrymore as Dr. Henry Jekyll / Mr. Edward Hyde

Brandon Hurst as Sir George Carewe

Martha Mansfield as Millicent Carewe

Charles Lane as Dr. Richard Lanyon

Cecil Clovelly as Edward Enfield

Nita Naldi as Miss Gina

Louis Wolheim as Music Hall Proprietor

Alma Aiken as Extra (uncredited)

J. Malcolm Dunn as John Utterson (uncredited)

Ferdinand Gottschalk as Old Man at Table in Music Hall (uncredited)

Julia Hurley as Hyde's Landlady with Lamp (uncredited)

Jack McHugh as Street Kid - Raises Fist to Mr. Hyde (uncredited)

Georgie Drew Mendum as Patron in Music Hall (uncredited)

Blanche Ring as Woman at Table with Old Man in Music Hall (uncredited)

May Robson as Prostitute at Clinic (uncredited)

George Stevens as Jekyll's Butler Poole (uncredited)

Edgard Varèse as Policeman (uncredited)