Harry Connick Jr. as Dr. Dennis Slamon

Tammy Blanchard as Nicole Wilson

Amanda Bynes as Jamie McGrath

Jennifer Coolidge as Tish

Angie Harmon as Lilly Tartikoff

John Benjamin Hickey as Blake Rogers

Regina King as Ellie Jackson

Swoosie Kurtz as Elizabeth

Paula Cale as Donna Slamon (as Paula Cale Lisbe)

Amy Madigan as Fran Visco

Bernadette Peters as Barbara Bradfield

Trudie Styler as Tina

Melissa McBride as Sally

J. Patrick McNamara as Dr. Rice

Jackson Hurst as Josh

Brandon Smith as Pharmacy Board Member