Art Parkinson as Kubo (voice)

Charlize Theron as Monkey / Mother (voice)

Brenda Vaccaro as Kameyo (voice)

Cary-Hiroyuki Tagawa as Hashi (voice)

Meyrick Murphy as Mari (voice)

George Takei as Hosato (voice)

Rooney Mara as The Sisters (voice)

Ralph Fiennes as Moon King (voice)

Matthew McConaughey as Beetle (voice)

Minae Noji as Minae (voice)

Alpha Takahashi as Aiko (voice)

Laura Miro as Miho (voice)

Ken Takemoto as Ken (voice)

Aaron Aoki as Villager (voice)

Luke Donaldson as Villager (voice)

Michael Sun Lee as Villager (voice)

Cary Y. Mizobe as Villager (voice)

Rachel Morihiro as Villager (voice)

Thomas Isao Morinaka as Villager (voice)

Saemi Nakamura as Villager (voice)

Zachary Alexander Rice as Villager (voice)

Mariel Sheets as Villager (voice)