Emily Blunt as Zoe Huntington (voice)

John Krasinski as Owen Huntington (voice)

Lydia Rose Taylor as Mackenzie Huntington (voice)

Ian McKellen as Horatio P. Huntington (voice)

Sylvester Stallone as Bullet-Man (voice)

Danny DeVito as Chesterfield (voice)

Patrick Warburton as Brock (voice)

Wallace Shawn as Mr. Woodley (voice)

Raven-Symoné as Brinkley (voice)

Gilbert Gottfried as Mario Zucchini (voice)

Tara Strong as Talia (voice)

Kevin Grevioux as Samson the Strongman (voice)

Anthony Sava as El Diablo (voice)

Brendan Sava as Young Owen (voice)

Alyssa Trama as Gretchen the Bearded Lady (voice)

Debi Derryberry as Additional Voices (voice)

Harvey Fierstein as Esmerelda (voice)