Jessica Biel as Alice Eckle

Jake Gyllenhaal as Howard Birdwell

James Marsden as Scott

Catherine Keener as Rep. Pam Hendrickson

Paul Reubens as Edwin

Kirstie Alley as Aunt Rita

James Brolin as Speaker Buck McCoy

Tracy Morgan as Keyshawn

Malinda Williams as Rakeesha

Kurt Fuller as Reverend Norm

David Ramsey as Rep. Bill Harshtone

Olivia Crocicchia as Marsha Weber

Bill Hader as Doctor Turnstall

Albert Gore III as Everett

Raymond L. Brown Jr. as Burger Hop Manager

Cheryl McConnell as Woman Administrator

Jenny Gulley as Brenda

Beverly D'Angelo as Helen Eckle

Steve Boles as Bob Eckle

Darlene Hunt as Doctor Adams

Kendrick Cross as Security Guard

Micah Shane Ballinger as Young Aide

Simon Hamlin as Man Reporter

Barbara Weetman as McCoy's Widow

Ronnie White as Reporter #1

Bonnie Aarons as Reporter #2

Rachel Mower as Squaw Girl

Daley Fricks as Squaw Girl

Matthew Muzio as Reporter

Bianca J. F. Goodwin as Squaw Girl

Mert Hatfield as Elk Man

Riley Badger as Squaw Girl

Ruby Rose Skotchdopole as Squaw Girl

Donna Scott as Lobbyist #1

Mary Firestone as Lobbyist #2

Scott Malyerck as Congressman

Joseph Washington as Network Anchor

Michael Harding as Insurance Lobbyist (uncredited)

Conrad Goode as The Father (uncredited)