Will Smith as Dr. Bennet Omalu

Alec Baldwin as Dr. Julian Bailes

Albert Brooks as Dr. Cyril Wecht

Gugu Mbatha-Raw as Prema Mutiso

David Morse as Mike Webster

Arliss Howard as Dr. Joseph Maroon

Mike O'Malley as Daniel Sullivan

Eddie Marsan as Dr. Steven DeKosky

Hill Harper as Christopher Jones

Adewale Akinnuoye-Agbaje as Dave Duerson

Stephen Moyer as Dr. Ron Hamilton

Richard T. Jones as Andre Waters

Paul Reiser as Dr. Elliot Pellman

Luke Wilson as Roger Goodell

Matthew Willig as Justin Strzelczyk

Elizabeth Tulloch as Keana Strzelczyk

Jason Davis as Defense Attorney

Sara Lindsey as Gracie

Kevin Jiggetts as FBI Agent

Gary Grubbs as FBI Agent

L. Scott Caldwell as Waters' Mother

Joni Bovill as Mrs. Scott

Joshua Elijah Reese as Graveyard Tech

Holt McCallany as Angry Neurologist

David Flick as Hospital Security Guard

Kelley Davis as Assistant

Samara Lee as Strzelczyk's Daughter

Nathan Hollabaugh as Young Reporter

Britanni Johnson as Rachel Green

Randy Kovitz as Deputy Mayor

Dan Ziskie as Paul Tagliabue

Larry John Meyers as Father D'Amico

Dan Anders as College Coach

Jeb Keller as High School Coach

Jackie Schafer as TV Reporter (Webster Site)

Mike Clark as TV Reporter (Interview)

Jared Pfennigwerth as Tech

Phillip Chorba as Tech

Alison Moir as Colleen Bailes

Dino Rende as Strzelczyk's Son

Cindy Jackson as Paramedic

Scott Miller as Contractor

Michael Schaich as Security Guard

Hennessey Joseph as NFL Employee

Antonia Long as Piano Player

Lisa Earley as Lodi Morgue Tech

Ann B. Betters as Cantor

Joe Fishel as Louisville Head Football Coach

Dihlon McManne as Reporter at Westin

Brittney Aleah as Altar Server (uncredited)

Christopher Boyer as Crockett (uncredited)

Deborah Charity as Attorney (uncredited)

Amy Lyn Elliott as Business Woman (uncredited)

Joe Gallipoli as Doctor (uncredited)

Carmen Gangale as Doctor (uncredited)

Trevor Lee Georgeson as NFL Mourner (uncredited)

David Gragg as Football Coach (uncredited)

Eme Ikwuakor as Amobi Okoye (uncredited)

Dontez James as Corpse (uncredited)

Wendell Kinney as NFL Football Player (uncredited)

David Dale McCue as Pittsburgh Police Officer (uncredited)

Ben McDonnell as Young Webster (uncredited)

Robert G. McKay as Mr. Scott (uncredited)

F. Robert McMurray as NFL Lawyer (uncredited)

Kimberly Ryans as Business Woman (uncredited)

P. Scott Conner as ER Doctor

Jared Scott as Justin Strelczyk (uncredited)

Jackson Nunn as Church Member (uncredited)