John Krasinski as John Hollar

Margo Martindale as Sally Hollar

Richard Jenkins as Don Hollar

Sharlto Copley as Ron Hollar

Anna Kendrick as Rebecca

Charlie Day as Jason

Mary Elizabeth Winstead as Gwen

Randall Park as Dr. Fong

Josh Groban as Reverend Dan

Mary Kay Place as Pam

Ashley Dyke as Stacey

Didi Costine as Matilda

Isabela Costine as Constance

Timothy Crowe as Loan Officer

Nancy Nave as OB Nurse

Yvonne Angulo as ER Nurse

Tonea Stewart as Latisha

Gus Sanchez as Pedro

Lacey Levy as Neurology Nurse

Debbie Prescott as Liquor Barn Cashier

Ashley Ailes as Nurse in Hallway

Taylor Berry as Labor Nurse

Sarah Smith as ICU Nurse #1

Stephanie Carmichael as ICU Nurse #2

Tucker Brady as ICU Nurse #3

Kristin Scoggins as ICU Nurse #4

William Schilling as Minister

Terence Mosley as Funeral Director

Millard Smith as Old Man in Wheelchair

Brenda Cavin as Old Man's Daughter

Hillary Schoelzel as ER Nurse #2

Finn as Photoshoot Dog

Patrick Kearns as Hospital Guest

Travis Turner as Doctor

Lamar Lott as Bank Patron

Emma Frances Burge as Airport Traveler (uncredited)

Vincent Eugene Hatten as Doctor (uncredited)

Aaron J. Brooks as Plane Passenger (uncredited)

Rhonda Jennings as Bank Teller (uncredited)

Brady Permenter as Boy on Bike (uncredited)