Shia LaBeouf as Sam Witwicky

Megan Fox as Mikaela Banes

Peter Cullen as Optimus Prime (voice)

Hugo Weaving as Megatron (voice)

Tony Todd as Fallen (voice)

Josh Duhamel as Major Lennox

Tyrese Gibson as USAF Chief Master Sergeant Epps

John Turturro as Simmons

Ramón Rodríguez as Leo Spitz

Kevin Dunn as Ron Witwicky

Julie White as Judy Witwicky

Isabel Lucas as Alice

John Benjamin Hickey as Galloway

Matthew Marsden as Special Air Service Forces

Andrew Howard as Special Air Service Forces

Michael Papajohn as Cal

Glenn Morshower as General Morshower

John Eric Bentley as Aide

Erin Naas as Arcee Rider

Rainn Wilson as Professor Colan

Katie Lowes as April the Resident Assistant

Jonathon Trent as Fassbinder

Walker Howard as Sharsky

America Olivo as Frisbee Girl

Aaron Hill as Frat Guy

Jareb Dauplaise as Frat Guy

John Sanderford as Pundit

Christopher Curry as Pundit

Cas Anvar as Egyptian Interpol Officer

Michael Benyaer as Egyptian Interpol Officer

Deep Roy as Egyptian Guard

Ruben Martinez as Bedouin with Donkey

Spencer Garrett as Air Force Chief of Staff

Ralph Meyering Jr. as NORAD General

Aaron Norvell as Air Force Military Police

Eric Pierpoint as NSA Officer

Annie Korzen as Simmons Mom

Sean T. Krishnan as Yakov

David Bowe as Smithsonian Guard

Kamal Jones as Smithsonian Guard

Aaron Lustig as Reporter

Jim Holmes as Reporter

Kristen Welker as Reporter

Cornell Womack as FBI Director

David Luengas as Ticket Agent

Derek Alvarado as Joint Ops Staff

Alex Fernandez as Joint Ops Staff

Casey Nelson as Joint Ops Staff

Jason Roehm as Joint Ops Staff

John Nielsen as USS Roosevelt Captain

Rick Cramer as Diego Garcia Soldier

Arnold Chun as Diego Garcia Soldier

Marvin Jordan as Diego Garcia Soldier

Marc Evan Jackson as Commander, US Central Command

Jayson Floyd as Strike Force Team

Aaron Garrido as Strike Force Team

Josh Kelly as Strike Force Team

Joel Lambert as Strike Force Team

David Paul Olsen as Strike Force Team

Geoff Reeves as Strike Force Team

Brian Shehan as Strike Force Team

Mark Ryan as Jetfire (voice)

Reno Wilson as Mudflap (voice)

Jess Harnell as Ironhide (voice)

Robert Foxworth as Ratchet (voice)

André Sogliuzzo as Sideswipe (voice)

Grey DeLisle as Arcee (voice)

Charlie Adler as Starscream (voice)

Frank Welker as Soundwave / Devastator / Reedman (voice)

Tom Kenny as Wheelie / Skids (voice)

Calvin Wimmer as Wheelbot (voice)

John Di Crosta as Doctor (voice)

Michael York as Prime #1 (voice)

Kevin Michael Richardson as Prime #2 / Skipjack (voice)

Robin Atkin Downes as Prime #3 (voice)

Jenn An as Astronomy Student (uncredited)

Alexandra Begg as College Student (uncredited)

Caitlin Dulany as CNN Reporter (uncredited)

Andrew Hwang as Mandarin Blogger (uncredited)

Matt Iseman as C-17 Pilot (uncredited)

Shayna Ryan as French Cafe Patron (uncredited)

Karina Michel as Reporter (uncredited)

Chester the Chihuahua as Mojo (uncredited)