Eliza Dushku as Pia Carter

Robert Patrick as Doctor H.H. Greiss

Chace Crawford as Jacob Martin

P.J. Byrne as Scott Carter

Brandon T. Jackson as Dell Richards

Nicole Forester as Genevieve Martin

Milica Govich as Nurse Fletcher

Ricky Wayne as Detective Frazer

Jordan Trovillion as Garage Girl

Heather Fairbanks as Nurse (uncredited)

Amber Whelan as Mental Patient (uncredited)

Camille Bresie Cooke as Nurse Carter

Art Beer as Arlen Davies

Annie Kitral as Administrator

Dan Lemieux as Orderly 1

Matt Philliben as Orderly 2

Big Ron Lyons as Orderly 3

John Lepard as Doctor

Anthony Bowden as Urban Explorer 1

Schuyler Whitesell as Urban Explorer 2

Josh Aspiranti as Familiar Orderly

Andrew Huff as Ragged Man

Anton Bassey as Fire Marshal

Mark Rademacher as Garage Owner

Tim Holmes as Huge Orderly

Paul W. Smith as Interviewer

Alan Cohen as Security Officer

Mary Jo Cuppone as Staff Doctor

Lawanda Starr Nance as Nurse

Jim Porterfield as Past Security Officer

Dan John Miller as The Patient

Alastar Dimitrie as Student 1

Tiren Jhames as Isaan Martin

Sofia Tepper as Young Pia

Jeremy Pastoria as Young Scott

Jessica Ashley as Candy Striper

Sandro Rodriguez as Orderly 4

John Dickerson as Old Patient

Michael James Alexander as Orderly (uncredited)

Billie Rae Bates as Mental Patient (uncredited)

Mary C. Bliss as Mental Patient (uncredited)

Michael Stephen Bryant as Mental Patient (uncredited)

Michael Bugard as Mental Patient (uncredited)

Tiffany Burns as Nurse (uncredited)

Deb Fernandez as Nurse (uncredited)

Michael Haase as Firefighter (uncredited)

Laura Hanna as Mental Patient (uncredited)

Krystal Huffman as Mental Patient (uncredited)

Martin Klebba as Mental Patient (uncredited)

Thomas Lee as Medical Intern (uncredited)

Eric M. Myrick as Orderly (uncredited)

Rose Anne Nepa as Mental Patient (uncredited)

Wendy Peterson as Mental Patient (uncredited)

Manny Sandow as Orderly (uncredited)

George Seder as Firefighter (uncredited)

Dawn Turchin as Student (uncredited)