Charles Bronson as Joe Valachi

Lino Ventura as Vito Genovese

Jill Ireland as Maria Reina Valachi

Walter Chiari as Dominick Petrilli, aka "Gap"

Joseph Wiseman as Salvatore Maranzano

Gerald S. O'Loughlin as Ryan, federal agent

Amedeo Nazzari as Gaetano Reina

Fausto Tozzi as Albert Anastasia

Pupella Maggio as Letizia Reina

Angelo Infanti as Lucky Luciano

Guido Leontini as Tony Bender

María Baxa as Donna Petrillo

Mario Pilar as Salierno

Franco Borelli as Buster

Alessandro Sperli as Giuseppe 'Joe the Boss' Masseria

Natasha Chevelev as Jane

Anthony Dawson as Federal Investigator

Fred Valleca as Buck

John Alarimo as Steven Ferrigno (uncredited)

Calogero Azzaretto as Man of the clan (uncredited)

Joe Don Baker as Irish member of Valachi gang (uncredited)

Steve Belloise as Winnie (uncredited)

Angelo Boscariol as Gangster (uncredited)

Nestore Cavaricci as Prisoner with Valachi (uncredited)

Giacomo De Michelis as Augie (uncredited)

Bruno Di Luia as Luciano's Henchman (uncredited)

Arny Freeman as Warden (uncredited)

Alfonso Giganti as Wedding party guest (uncredited)

Ron Gilbert as Prison Guard (uncredited)

Frank Gio as Frank (uncredited)

Syl Lamont as Commander of Fort Monmouth (uncredited)

Imelde Marani as Donna Petrillo's friend (uncredited)

Isabelle Marchall as Mary-Lou (uncredited)

Jason McCallum as Donald Valachi (uncredited)

Sabine Sun as Jane (uncredited)

Robert Trout as Self (uncredited)

Franco Ressel as (uncredited)

Richard Dunne as Judge (uncredited)