Milla Jovovich as Kate Abbott

Pierce Brosnan as The Watchmaker

Dylan McDermott as Sam Parker

Angela Bassett as Maureen Cranepaul

Robert Forster as Bill Talbot

James D'Arcy as Paul Anderson

Roger Rees as Dr. Emil Balan

Genevieve O'Reilly as Lisa Carr

Frances de la Tour as Sally

Sonya Cassidy as Helen

Antonia Thomas as Naomi Rosenbaum

Sean Teale as Alvin Murdock

Regé-Jean Page as Robert Purvell

Jing Lusi as Joyce Su

Benno Fürmann as Zafer Pavlou

Paddy Wallace as Johnny Talbot

Parker Sawyers as Ray

Eddie Bagayawa as garbageman (uncredited)

Alexis Peterman as Flight Attendant

Steven Robertson as Trevor

Katarzyna Wolejnio as Margaret Richards

Dimo Alexiev as Waiter

Corey Johnson as Eric Loomis

Ryan Stuart as Nero Franks (uncredited)

Bashar Rahal as Militiaman #2

Susannah Allman as Ticket Agent #2

Ben Starr as Sniper

Ronan Summers as Marine (uncredited)