Will Arnett as Surly (voice)

Maya Rudolph as Precious (voice)

Bobby Cannavale as Frankie (voice)

Bobby Moynihan as The Mayor (voice)

Isabela Merced as Heather (voice)

Peter Stormare as Gunther (voice)

Gabriel Iglesias as Jimmy (voice)

Jeff Dunham as Mole (voice)

Sebastian Maniscalco as Johnny (voice)

Kari Wahlgren as Jamie / Additional Voices (voice)

Jackie Chan as Mr. Feng (voice)

Katherine Heigl as Andie (voice)

Julie Lemieux as Lil' Chip (voice)

Dwayne Hill as Police Officer (voice)

Josh Robert Thompson as Construction Foreman (voice)

Rob Tinkler as Redline (voice)

Jess Harnell as Animal Control Guy 1 (voice)

Fred Tatasciore as Animal Control Guy 2 (voice)

Andrew Ortenberg as Animal Control Guy 3 (voice)

Greg Chun as Mouse Henchman (voice)

Dave Fennoy as Mouse Henchman 2 (voice)

Laraine Newman as Daredevil Chipmunk (voice)

Justin Felbinger as Young Surly (voice)

Cal Brunker as Charming Chipmunk (voice)

Bob Barlen as Handsome Mouse (voice)

Lukas Engel as Additional Voices (voice)