Christopher Plummer as Sherlock Holmes

James Mason as Dr. Watson

David Hemmings as Inspector Foxborough

Susan Clark as Mary Kelly

Anthony Quayle as Sir Charles Warren

John Gielgud as Prime Minister

Frank Finlay as Inspector Lestrade

Donald Sutherland as Robert Lees

Geneviève Bujold as Annie Crook

Chris Wiggins as Dr. Hardy

Tedde Moore as Mrs. Lees

Catherine Kessler as Carrie

Terry Duggan as Danny

Peter Jonfield as William Slade

Roy Lansford as Sir Thomas Spivey

Ron Pember as Makins

Ken Jones as Dock Guard

June Brown as Annie Chapman

Hilary Sesta as Catherine Eddowes

Anthony May as Lanier

Betty Woolfe as Mrs. Hudson

Iris Fry as Elizabeth Stride

Geoffrey Russell as Home Secretary

Peggy Ann Clifford as Lees' Housekeeper

Ann Mitchell as Jane

Katherine Stark as Molly

Elaine Ives-Cameron as Ellen

Stella Courtney as Betty

Judy Wilson as Emily

Roy Pattison as Carroll

Victor Langley as Prince of Wales

Pamela Abbott as Princess Alexandra

Robin Marchal as Duke of Clarence "Eddy"

Richard Pescud as Doctor

Pat Brackenbury as Nurse

Dan Long as Constable Long

Michael Cashman as Constable Watkins

Tony Clarkin as Police Sergeant (uncredited)

Peter Dean as Police Constable (uncredited)

Jim McManus as Policeman (uncredited)

Norman Gay as Distinguished Gentleman (uncredited)