Adrien Brody as Royce

Topher Grace as Edwin

Alice Braga as Isabelle

Oleg Taktarov as Nikolai

Laurence Fishburne as Noland

Walton Goggins as Stans

Danny Trejo as Cuchillo

Louis Ozawa as Hanzo

Mahershala Ali as Mombasa

Brian Steele as Berserker Predator / Falconer Predator

Derek Mears as Classic Predator

Carey Jones as Tracker Predator

Aaron Richardson as Rocky (uncredited)