Adrien Brody as Royce

Topher Grace as Edwin

Alice Braga as Isabelle

Walton Goggins as Stans

Oleg Taktarov as Nikolai

Laurence Fishburne as Noland

Danny Trejo as Cuchillo

Louis Ozawa as Hanzo

Mahershala Ali as Mombasa

Carey Jones as Tracker Predator

Brian Steele as Berserker Predator / Falconer Predator

Derek Mears as Classic Predator

Aaron Richardson as Rocky (uncredited)