Dan Castellaneta as Homer Simpson / Itchy / Barney / Abe Simpson / Stage Manager / Krusty the Clown / Mayor Quimby / Mayor's Aide / Multi-Eyed Squirrel / Panicky Man / Sideshow Mel / Mr. Teeny / EPA Official / Kissing Cop / Bear / Boy on Phone / NSA Worker / Officer / Santa's Little Helper / Squeaky-Voiced Teen (voice)

Julie Kavner as Marge Simpson / Selma Bouvier / Patty Bouvier (voice)

Nancy Cartwright as Bart Simpson / Maggie Simpson / Ralph / Nelson / Todd Flanders / TV Daughter / Woman on Phone (voice)

Yeardley Smith as Lisa Simpson (voice)

Hank Azaria as Professor Frink / Comic Book Guy / Moe / Chief Wiggum / Lou / Carl / Cletus / Bumblebee Man / Male EPA Worker / Dome Depot Announcer / Kissing Cop / Carnival Barker / Counter Man / Apu / Drederick Tatum / Sea Captain / EPA Passenger / Robot / Dr. Nick / Wise Guy (voice)

Harry Shearer as Scratchy / Mr. Burns / Rev. Lovejoy / Ned Flanders / Lenny / Skull / President Arnold Schwarzenegger / Kent Brockman / Principal Skinner / Dr. Hibbert / Smithers / Toll Booth Man / Guard / Otto / Kang (voice)

Pamela Hayden as Milhouse Van Houten / Jimbo Jones / Rod Flanders (voice)

Tress MacNeille as Sweet Old Lady / Colin / Mrs. Skinner / Nelson's Mother / Pig / Cat Lady / Female EPA Worker / G.P.S. Woman / Cookie Kwan / Lindsey Naegle / TV Son / Medicine Woman / Girl on Phone (voice)

Albert Brooks as Russ Cargill (voice)

Karl Wiedergott as Man / EPA Driver (voice)

Marcia Wallace as Edna Krabappel (voice)

Russi Taylor as Martin Prince (voice)

Maggie Roswell as Helen Lovejoy (voice)

Phil Rosenthal as TV Dad (voice)

Billie Joe Armstrong as Billie Joe Armstrong (voice)

Mike Dirnt as Mike Dirnt (voice)

Tré Cool as Tre Cool (voice)

Joe Mantegna as Fat Tony (voice)

Tom Hanks as Tom Hanks (voice)