Meryl Streep as Miranda Priestly

Anne Hathaway as Andy Sachs

Emily Blunt as Emily

Stanley Tucci as Nigel

Simon Baker as Christian Thompson

Adrian Grenier as Nate

Tracie Thoms as Lily

Rich Sommer as Doug

Daniel Sunjata as James Holt

David Marshall Grant as Richard Sachs

James Naughton as Stephen

Tibor Feldman as Irv Ravitz

Rebecca Mader as Jocelyn

Jimena Hoyos as Lucia

Gisele Bündchen as Serena

George C. Wolfe as Paul

John Rothman as Editor

Stephanie Szostak as Jacqueline Follet

Colleen Dengel as Caroline

Suzanne Dengel as Cassidy

Heidi Klum as Heidi Klum

Valentino Garavani as Valentino Garavani

Bridget Hall as Bridget Hall

Ines Rivero as Clacker in Elevator

Alyssa Sutherland as Clacker

Robert Verdi as Fashion Reporter

Paul Keany as St. Regis Butler

David Callegati as Massimo

Rori Cannon as Girl at Party

Stan Newman as John Folger

James Cronin as Ambassador

Eric Seltzer as Roy

Lindsay Brice as PR Woman

Steve Benisty as Fashion Photographer

John Graham as Book Guy

Wells Dixon as Miranda's Driver

Ilona Alexandra as Red Carpet Celebrity (uncredited)

Frank Anello as Security (uncredited)

Alexander Blaise as French Bellhop (uncredited)

Carl Burrows as Businessman (uncredited)

Guy A. Fortt as Security (uncredited)

Alexie Gilmore as Clacker (uncredited)

Toree Hill as Guest (uncredited)

Tim Krueger as Fund Raiser (uncredited)

Hector Lincoln as Hector Lincoln (uncredited)

Nina Lisandrello as Clacker (uncredited)

Zev McAllister as Runway Editor (uncredited)

Matt Murray as Paparazzo (uncredited)

Ingrid Sophie Schram as Clacker (uncredited)

Bobby Shue as Runway Staff (uncredited)

Brandhyze Stanley as Waitress (uncredited)

Jen Taylor as Lou - Dowager (uncredited)

Taylor Treadwell as Miranda's New Assistant (uncredited)

Donatella Versace as Donatella Versace (uncredited)

Lauren Weisberger as The Twins' Nanny (uncredited)

Laura D. Williams as Runway Magazine Model / Party Guest (uncredited)