Demi Moore as Claire Donnelly

Sissy Spacek as Barbara Barrows

Cher as Dr. Beth Thompson

Shirley Knight as Mary Donnelly

Catherine Keener as Becky

Jason London as Kevin Donnelly

CCH Pounder as Jenny Ford

Kevin Cooney as Dr. Kramer

Robin Gammell as Jim Donnelly

Phyllis Lyons as Audrey

Aaron Lustig as Tom

Dena Burton as Young Nurse

Marie DeCicco as Annie Ross

Lorna Scott as Louise

Mary Portser as Margaret

Annie Weldon as Nurse

Vaughn Armstrong as Painter

Jack Kehler as Cab Driver

Tim DeKay as Becky's Husband

Jamy Myatt as Rose

Bob Shuttleworth as Hospital Visitor

Xander Berkeley as John Barrows

Hedy Burress as Linda Barrows

Janna Michaels as Sally Barrows

Ian Bohen as Scott Barrows

Zack Eginton as Ryan Barrows

Joanna Gleason as Julia

Harris Yulin as Professor Speras

Jordana Spiro as Alison

Michael David Carter as Student

Tyffany Kyler as Student

Anne Heche as Christine Cullen

Jada Pinkett Smith as Patti

Eileen Brennan as Tessie

Lindsay Crouse as Frances White

Craig T. Nelson as Jim Harris

Diana Scarwid as Marcia Schulman

Lorraine Toussaint as Shameeka Webb

Rita Wilson as Leslie

Georganne LaPiere as Clinic Director

Sally Murphy as Doreen

Rusty Schwimmer as Prayer Group

Christine Avila as Prayer Group

Chris Ellis as Crowd Leader

Matthew Lillard as Young Couple

Susie Spear Purcell as Young Couple

Brendan Ford as Corey

Rob Camilletti as Photographer

Sarah Koskoff as Female Testimonial

Robert Wisdom as Policeman

Judith Drake as Angry Woman

Geoffrey Nauffts as Angry Man

Ben Marley as Man in Crowd

Carmen Thomas as Nurse

Aaron James Cash as David

Hilda Stark as Second Hand Rose Clark

Lisa Marie Boiko as Receptionist

Michele Fischer as Angry Girl

Marlene Sosebee as Officer Myers