John Travolta as James

Kirstie Alley as Mollie

Olympia Dukakis as Rosie

George Segal as Albert

Abe Vigoda as Grandpa

Bruce Willis as Mikey (voice)

Twink Caplan as Rona

Jason Schaller as Mikey

Jaryd Waterhouse as Mikey

Jacob Haines as Mikey

Christopher Aydon as Mikey

Joy Boushel as Melissa

Don S. Davis as Dr. Fleischer

Louis Heckerling as Lou

Brenda Crichlow as Secretary

Andrea Mann as Salesgirl

Douglas Tuck as Cab Stealer

Alex Bruhanski as Street Worker

Casey Grant as Admitting Clerk

Oscar B. Ramos as Hospital Worker

Aurelio Dinunzio as Orderly

Jeff Irvine as Admitting Doctor

Shirley Barclay as Nurse

William B. Davis as Drug Doctor

David Berner as Mr. Impatience

Jerry Wasserman as Mr. Anal

Daliah Novak as Carrie

Zena Darawalla as Lupe

Nicholas Rice as Harry

Neal Israel as Mr. Ross

Blu Mankuma as Director

William Britos as Home Orderly

Dee Jay Jackson as Burly Orderly

Ida Berner as Lady

Bea Cartmell as Lady

Eleanor Maines as Lady

Mollie Heckerling as Little Girl

Ryan McIntosh as Little Boy

Gerry Bean as Pilot Friend

Deryl Hayes as Pilot Friend

Enid Saunders as Ester

Nicole Stevens as Silly Baby

Christy Smith as Baby Megan

Sabrina Bailey as Sand Box Baby

Farah Abassi as Chatting Baby

Amber Brownmiller as Blowing Kiss Baby

Ariel Perryman as Nursery Baby

Nigel John Crowe as Nursery Baby

Michael Joseph Materi as Nursery Baby

Joan Rivers as Julie (voice) (uncredited)

Aaron Jefford as Fireman (uncredited)