Woody Harrelson as Lyndon B. Johnson

Michael Stahl-David as Robert F. Kennedy

Richard Jenkins as Sen. Richard Russell

Jennifer Jason Leigh as Lady Bird Johnson

Jeffrey Donovan as John F. Kennedy

Bill Pullman as Ralph Yarborough

Brian Stepanek as Rufus Youngblood

Tim Ransom as Larry O'Brien

C. Thomas Howell as Walter Jenkins

Doug McKeon as Hubert H. Humphrey

Rich Sommer as Pierre Salinger

Gary Grubbs as Everett Dirksen

John Burke as John Connally

Kim Allen as Jacqueline Kennedy

Brent Bailey as Ted Sorensen

Joe Chrest as McGeorge Bundy

Judd Lormand as Robert McNamara

Dan Hewitt Owens as Abe Fortas

John Ellison Conlee as George Reedy

Michael Mosley as Kenny O’Donnell

Darrel Guilbeau as Jack Valenti

Oliver Edwin as Bill Moyers

Aaron Mitchell as Senator / Police Officer (uncredited)