Owen Wilson as Kyle Reynolds

Ed Helms as Peter Reynolds

J.K. Simmons as Ronald Hunt

Katt Williams as Hitchhiker

Terry Bradshaw as Terry Bradshaw

Ving Rhames as Rod Hamilton

Christopher Walken as Dr. Walter Tinkler

Glenn Close as Helen Baxter

Katie Aselton as Sarah O'Callaghan

Retta as Annie

Harry Shearer as Gene

June Squibb as Mrs. Hunt

Ali Wong as Ali

Robert Mello as Mr. Jensen

Zachary Haven as Ethan

Mary Grill as Katherine

Ann McKenzie as Sheila

Jessica Gomes as Kaylani

Sarah Skeist as Pretty Flight Attendant

Debra Stipe as Karen Bradshaw

Robert Pralgo as Ferrari Owner

Niki Davis as Ferrari Owner's Wife

Donna DuPlantier as ER Doctor

Robert Walker Branchaud as Officer #1

B'nard Lewis as Officer #2

Andrew Wilson as Hotel Desk Clerk

Ryan Cartwright as Liam O'Callaghan

Ryan Gaul as Sean O'Callaghan

Taylor Treadwell as Kelly

Jack McGee as Kevin O'Callaghan

Jim France as Father McManus

Jo Helton as Elderly Woman

Liam Tomasiello as Alex