Rodolfo Sancho as Fernando II de Aragón

Irene Escolar as Juana I de Castilla

Raúl Mérida as Felipe I de Castilla

Eusebio Poncela as Cardenal Cisneros

Ramón Madaula as Gonzalo Chacón

Jordi Díaz as Andrés de Cabrera

Fernando Guillén Cuervo as Gutierre Gómez de Fuensalida

Úrsula Corberó as Margarita de Austria

Silvia Alonso as Germana de Foix

Jose Coronado as Maximiliano I de Habsburgo

Pedro Mari Sánchez as Pedro Manrique de Lara y Sandoval

Ramón Barea as Fadrique Álvarez de Toledo y Enríquez

Fernando Cayo as Guillermo de Veyré

Jacobo Dicenta as Juan Belmonte

Jesús Noguero as Alonso Pimentel y Pacheco

Ainhoa Santamaría as Beatriz de Bobadilla

Carolina Lapausa as Juana de Aragón

Michelle Jenner as Isabel I de Castilla

Antonio Gil as Bernardino Fernández de Velasco y Mendoza

Arón Piper as Fernando I de Habsburgo

Moncho Sánchez-Diezma as Secretario de Córtes

David Lorente as Doctor de la Parra

Martín Castro Peña as Monje de Cartijo

Fernando Valdivielso as Archiduque de Felipe

Carlota Ferrer as Dama de Juana

Betsy Túrnez as Blanca de Herrera Juana de Aragón