John Abraham as Ajju Bhai / Ajay

Shruti Haasan as Ranjana Shetty

Anil Kapoor as Sagar 'Majnu' Pandey

Nana Patekar as Uday Shankar Shetty

Dimple Kapadia as Poonam

Paresh Rawal as Dr. Ghunghroo

Naseeruddin Shah as Wanted Bhai

Shiney Ahuja as Honey

Om Puri as Narrator (voice) (uncredited)

Rajpal Yadav as The Tailor

Ranjeet Bedi as Kapoor

Adi Irani as Uday's Lawyer (uncredited)

Lauren Gottlieb as Special Appearance in "20-20" Song

Reema Debnath as Special Appearance in "20-20" Song

Akshay Kumar as Rajiv (uncredited)

Supriya Karnik as Payal Ghungroo

Neeraj Vora as Badshah Khan

Surveen Chawla as Self

Shubhi Sharma as Self

Mushtaq Khan as Ballu