Lionel Barrymore as Dr. Leonard Gillespie

Philip Dorn as Dr. John Hunter Gerniede

Donna Reed as Marcia Bradburn

Phil Brown as Roy Todwell

Nat Pendleton as Joe Weyman

Alma Kruger as Molly Byrd

Mary Nash as Emma Hope

Walter Kingsford as Dr. Carew

Nell Craig as Nosey Parker

Ruth Tobey as Susan Prentiss

Jonathan Hale as Frank M. Todwell

Charles Dingle as Dr. Ward O. Kenwood

Marie Blake as Sally

Nana Bryant as Mrs. Todwell

Eddie Acuff as Clifford

Robin Raymond as Bubbles

Ava Gardner as Student (uncredited)

Emmett Vogan as Lt. Clifton (uncredited)

Harry Hayden as Auto Salesman (uncredited)

Joe Yule as Pedestrian (uncredited)

Charles Dorety as Waiter (uncredited)

Patrick McVey as Police Sergeant Hartwell (uncredited)

Ray Teal as Detroit Policeman (uncredited)

Philip Van Zandt as Detroit Dance Hall Waiter (uncredited)