Amy Schumer as Emily Middleton

Goldie Hawn as Linda Middleton

Tom Bateman as James

Christopher Meloni as Roger Simmons

Wanda Sykes as Ruth

Ike Barinholtz as Jeffrey Middleton

Óscar Jaenada as Morgado

Randall Park as Michael

Joan Cusack as Barb

Raven Goodwin as Lew

Arturo Castro as Dr. Armando

Bashir Salahuddin as Morgan Russell

Nicholas J. Lockwood as Jacob

Pedro Haro as Maco

Katie Dippold as Shopper

Kim Caramele as Shopper

Daniel Bess as Front Desk Clerk

Moani Hara as Hot Woman

Carlos Diaz as Guitar Player / Singer

Damion Scandrick as Tattooed Kidnapper

Andre Derizans as Kidnapper #2

Modesto Cordero as Pickup Truck Driver

Sergio Sanchez as Teen Bartender

Jason Quinn as Crew Member

Luis R. Espinoza as Taxi Driver

Linda Molina as Female Villager

Al Madrigal as Embassy Official

Erik-Alexander Sanchez as Embassy Worker

Tom Choi as Colonel

Kevin Kane as Hot Guy

Jenny Babas as Dancer (uncredited)

Miguel A. Baez Jr. as Henchman (uncredited)

Francis Benhamou as Colombian Army Commander (uncredited)

Raj K. Bose as Equadorian Bar Patron (uncredited)

Svitlana Campbell as Hotel Guest (uncredited)

Sasha Chuidian as Rioter (uncredited)

Wolf Lee Counsel as Restaurant Patron (uncredited)

Victoria Current as Prostitute (uncredited)

Shaun Dunnigan as Security Guard (uncredited)

Cody Easterbrook as Busboy (uncredited)

Jiaoying Liang as Dancer (uncredited)

Cat Limket as Beautiful Village Girl (uncredited)

Shawn McBride as International Hotel Guest (uncredited)

Andre Pelzer as International Hotel Guest (uncredited)

Ty Quiamboa as Bartender (uncredited)

Sandy Ritz as Hotel Guest (uncredited)

Scott M. Schewe as International Hotel Guest (uncredited)

David James Sikkink as International Hotel Guest (uncredited)

Rebecca Teresia as International Hotel Guest (uncredited)