Dustin Hoffman as Raymond Babbitt

Tom Cruise as Charlie Babbitt

Valeria Golino as Susanna

Gerald R. Molen as Dr. Bruner

Jack Murdock as John Mooney

Michael D. Roberts as Vern

Ralph Seymour as Lenny

Lucinda Jenney as Iris

Bonnie Hunt as Sally Dibbs

Kim Robillard as Small Town Doctor

Beth Grant as Mother at Farm House

Dolan Dougherty as Farm House Kid

Marshall Dougherty as Farm House Kid

Patrick Dougherty as Farm House Kid

John-Michael Dougherty as Farm House Kid

Peter Dougherty as Farm House Kid

Andrew Dougherty as Farm House Kid

Loretta Wendt Jolivette as Dr. Bruner's Secretary

Donald E. Jones as Minister at Funeral

Bryon P. Caunar as Man in Waiting Room

Donna J. Dickson as Nurse

Earl Roat as Man on Wallbrook Road

William Montgomery Jr. as Wallbrook Patient Entering TV Room

Elizabeth Lower as Bank Officer

Michael C. Hall as Police Officer at Accident

Robert W. Heckel as Police Officer at Accident

W. Todd Kenner as Police Officer at Accident

Kneeles Reeves as Amarillo Hotel Owner

Jack W. Cope as Irate Driver

Nick Mazzola as Blackjack Dealer

Ralph Tabakin as Shift Boss

Ray Baker as Mr. Kelso

Isadore Figler as Pit Boss

Ralph M. Cardinale as Pit Boss

Sam Roth as Floorman

Nanci M. Harvey as Lady at Blackjack Table

Kenneth E. Lowden as Guard in Video Room

Jocko Marcellino as Las Vegas Crooner

John Thorstensen as Train Conductor

Blanche Salter as Woman at Pancake Counter

Jake Hoffman as Boy at Pancake Counter

Royce D. Applegate as (voice)

June Christopher as (voice)

Anna Mathias as (voice)

Archie Hahn as (voice)

Luisa Leschin as (voice)

Ira Miller as (voice)

Chris Mulkey as (voice)

Tracy Newman as (voice)

Julie Payne as (voice)

Reni Santoni as (voice)

Bridget Sienna as (voice)

Ruth Silveira as (voice)

Jonathan Stark as (voice)

Lynne Marie Stewart as (voice)

Arnold F. Turner as (voice)

Gigi Vorgan as (voice)

Jon Bielich as Truck Driver (uncredited)

Richard A. Buswell as Car Driver (uncredited)

Pui Fan Lee as Casino Patron (uncredited)

Matt Mattingly as Autistic Pianist (uncredited)

Billie Perkins as Hotel Customer (uncredited)

Jill Senter as Sandra (uncredited)

Aaron Weiler as Airport Security Guard (uncredited)

Mark Winn as Restaurant Patron (uncredited)

Darryl Wooten as Blackjack Dealer (uncredited)

Fred Astaire as Self (archived footage)