Dustin Hoffman as Michael Dorsey / Dorothy Michaels

Jessica Lange as Julie Nichols

Teri Garr as Sandy Lester

Dabney Coleman as Ron Carlisle

Charles Durning as Les Nichols

Bill Murray as Jeff Slater

Sydney Pollack as George Fields

George Gaynes as John Van Horn

Geena Davis as April

Doris Belack as Rita

Ellen Foley as Jacqui

Peter Gatto as Rick

Lynne Thigpen as Jo

Ronald L. Schwary as Phil Weintraub

Debra Mooney as Mrs. Mallory

Amy Lawrence as Amy

Kenny Sinclair as Boy

Susan Merson as Page

Robert D. Wilson as Stage Hand

James Carruthers as Middle-Aged Man

Estelle Getty as Middle-Aged Woman

Christine Ebersole as Linda

Bernie Pollack as Actor #1

Sam Stoneburner as Actor #2

Marjorie Lovett as Salesgirl

Barbara Spiegel as Billie

Suzanne von Schaack as Party girl

Anne Shropshire as Mrs. Crawley

Murray Schisgal as Party guest

Richard Whiting as Priest

Jim Jansen as Stage Manager #2

Tom Mardirosian as Stage Manager

Gavin Reed as Director

Annie Korzen as Autograph Hound

Ibbits Warriner as Autograph Hound

Lois de Banzie as Autograph Hound

Stephen Prutting as Autograph Hound

Tobin Bell as Waiter (uncredited)

Phillip Borsos as (uncredited)

Jim Dratfield as Acting Student (uncredited)

John Kapelos as Actor at Party (uncredited)

Joyce Worsley as Shocked Bystander as Dorothy Grabs a Cab (uncredited)

Andy Warhol as Andy Warhol (uncredited)

Pamela Lincoln as Secretary

Michael M. Ryan as Middle-Aged Man

Gene Shalit as Self (uncredited)