Katherine Heigl as Holly Berenson

Josh Duhamel as Eric Messer

Josh Lucas as Sam

Alexis Clagett as Sophie

Brynn Clagett as Sophie

Brooke Clagett as Sophie

Hayes MacArthur as Peter Novak

Christina Hendricks as Alison Novack

Sarah Burns as Janine Groff

Jessica St. Clair as Beth

Brooke Liddell as Older Sophie

Kiley Liddell as Older Sophie

Britt Flatmo as Amy

Rob Huebel as Ted

Melissa McCarthy as DeeDee

DeRay Davis as Lonnie

Kumail Nanjiani as Simon

Andy Daly as Scott

Bill Brochtrup as Gary

Will Sasso as Josh

Majandra Delfino as Jenna

Jason MacDonald as Cousin

Tara Ochs as Cousin's Wife

Wilbur Fitzgerald as Peter's Dad

Melissa Ponzio as Victoria (Stripper Cousin)

Reggie Lee as Alan Burke

Markus Flanagan as Chef Phillipe

Brooke Josephson as Liz

Chan Ta Rivers as CPS Worker

Eric Phillips as Stoned Teenager

Andy Buckley as George Dunn

L. Warren Young as Officer Young

Johanna Jowett as Jill

Jody Thompson as Worker

Horace Toney as Court Clerk

Millie Fairchild as Older Woman

Rob Nagle as Neighbor Dad

Katie Kneeland as Female Patron

Patricia French as Judge Gorling

Ron Clinton Smith as Contractor

Antwan Mills as Airport Security

Steve Nash as Self

Shayne Kohout as Pregnant Woman with DeeDee

Danielle L. Grant as Ticket Counter Lady

Eddie Frierson as Sports Announcer (voice)

Jean Smart as Helen Berenson (uncredited)