Katherine Heigl as Jane Nichols

James Marsden as Kevin Doyle

Malin Åkerman as Tess Nichols

Judy Greer as Casey

Edward Burns as George

Melora Hardin as Maureen

Brian Kerwin as Hal Nichols

Maulik Pancholy as Trent

David Castro as Pedro

Krysten Ritter as Gina the Goth

Michael Paul as Taxi Fahrer Khaleel

Jennifer Lim as Bridal Salesgirl

Danielle Skraastad as Bride Suzanne

Yetta Gottesman as Hip Bridesmaid

Erin Fogel as Shari Rabinowitz

Bern Cohen as Rabbi

Brigitte Bourdeau as Salesgirl Olga

Peyton List as Young Jane

Charli Barcena as Young Tess

Jane Pfitsch as Cousin Lisa

Laksh Singh as Hindu Priest

Lyralen Kaye as Yoga Instructor

Ronald Guttman as Antoine

Ron Simons as Boathouse Chef

Robert Clohessy as Dive Bartender

Michael Mosley as Bar Dude

Alyssa Bresnahan as Diner Waitress

Ellen H. Schwartz as Diner Waitress

Jennifer Bassey as Jane's Aunt

Alexa Havins as Boat Bride

Richard O'Rourke as Jane's Minister

Kathryn Weisbeck as Tara Bride (uncredited)