Sidney Toler as Charlie Chan

Victor Sen Yung as Jimmy Chan

Leo G. Carroll as Professor Gordon

Lionel Atwill as Dr. Suderman

Robert Lowery as Dick Kenyon

Marjorie Weaver as Paula Drake

Cora Witherspoon as Susie Watson

Don Beddoe as Frederick Ross

Leonard Mudie as Gerald Pendleton

Charles Middleton as Jeremiah Walters

Claire Du Brey as Sarah Walters

James Burke as Wilkie, house detective

Richard Keene as Buttons, ship's steward

Harry Strang as Seaman Guarding Pendleton

Harlan Briggs as San Francisco Coroner

Layne Tom Jr. as Willie Chan

C. Montague Shaw as Inspector Duff

Cliff Clark as Lieutenant Wilson

Kay Linaker as Linda Pendleton

Paul McVey as Mrs. Pendleton's Doctor

Wade Boteler as Honolulu Police Chief

Emmett Vogan as Hotel Manager

John Dilson as Police Doctor at Hotel

J. Anthony Hughes as Detective Wilson, Chan's agent

Sherry Hall as Radio Operator (uncredited)

Walter Miller as Ship's Officer (uncredited)

Al Kikume as Cop Extra in Chan's Office