Whoopi Goldberg as Bernice 'Bernie' Rhodenbarr

Bobcat Goldthwait as Carl Hefler

G.W. Bailey as Ray Kirschman

Lesley Ann Warren as Dr. Cynthia Sheldrake

John Goodman as Detective Nyswander

Vyto Ruginis as K.E. Graybow

James Handy as Carson Verrill

Anne DeSalvo as Detective Todras

Elizabeth Ruscio as Frankie

Larry Mintz as Vincent 'Knobby' DiCarno

Raye Birk as The Jogger

Eric Poppick as Deliveryman

Scott Lincoln as Man in Cadillac

Thom Bray as Shoplifter in Bookstore

Jack O'Leary as Ray's Friend

Mike Pniewski as Man in Grey Uniform #1

Ethan Phillips as Bartender at Parker's on Fifth

Michael Nesmith as Cabbie

Hugh Wilson as Customer at Mayday

Nathan Davis as Mr. Paggif

Brenda Hayes as Dental Receptionist

Lia Sargent as Dental Receptionist

Brett Marx as Dental Hygienist

Stephen Shellen as Christopher Marshall

Fredi Olster as Woman in Hallway

Rick Hamilton as Man in Hallway

Barbara Simpson as TV Reporter

Dennis Richmond as TV Anchorman

Robert Ernst as Officer with Warrant

Bill Jelliffe as Officer with Searchlight

Jay Hirsch as Man in Grey Uniform 2

Gary Hershberger as Young Officer

John H. Fields as Officer

Jo Anna March as Mrs. Kirschman

David J. Partington as Ray's Friend

John LeFan as Customer at Parker's on Fifth

Margaret Lenzey as Waitress at Parker's on Fifth

Ron Molina as Customer at The Art Bar

Amy Michelson as Waitress at The Art Bar

The Distance as Art Bar Band

Spike Sorrentino as Chief of Detectives

Jack Andreozzi as Knobby's Apartment Manager

John Frederick Jones as Dr. Sheldrake's Doorman

Al Pugliese as IBM Man

Justin De Rosa as IBM Man

Vincent Pantone as IBM Man

Brian Ann Zoccola as Verrill's Secretary

Elaine Corral Kendall as TV Anchorwoman

Conrad Hurtt as Dental Assistant (uncredited)