Michael J. Fox as Jay-Jay Manners

Nancy McKeon as Beth Franklin

Todd Bridges as Otto Lipton

Angela Cartwright as Miss D'Angelo

Bob Denver as Milton Feld

Dwayne Hickman as Mr. Plaza

Lauri Hendler as Nadine

Dana Plato as Cara Ames

Crystal Bernard as Anne-Marie Conklin

Anthony Edwards as Beau Middleton

Frank Bank as Mr. Gerardi

Elinor Donahue as Mrs. Franklin

Tony Dow as Principal Pete Kinney

Steve Franken as Dr. Fritz Hauptmann

David Nelson as Mr. Krinsky, Janitor

Ken Osmond as Baxter Franklin

Dawn Wells as MIss Lorilee Lee

Jon Caliri as Jerry

David Packer as Danny

Crispin Glover as Archie Feld

Cathy Silvers as Peggy

Jon Gries as Dirty Curt

Michael Zorek as Chuckie Dipple

Tom Villard as Crazy Leo Bandini

Barry Livingston as Mr. Sirota

Kelly Ann Conn as Swoozie

Kaley Ward as Chris

Jerry Maren as Robot

John Richard Petersen as Boy at Ferris Wheel (uncredited)