Frank Welker as Scooby-Doo / Fred Jones (voice)

Grey DeLisle as Daphne Blake (voice)

Matthew Lillard as Shaggy Rogers (voice)

Kate Micucci as Velma Dinkley (voice)

Dee Bradley Baker as Sea Creature / Malt Shop Walt / Zombie (voice)

JB Blanc as Atticus Fink / Director (voice)

Christian Lanz as Bryan Lakeshore / Mummy (voice)

Scott Menville as Junior (voice)

Cassandra Peterson as Drella Diabolique (voice)

James Arnold Taylor as Chet Brickton / Narrator (voice)