Melissa McCarthy as Lee Israel

Richard E. Grant as Jack Hock

Dolly Wells as Anna

Ben Falcone as Alan Schmidt

Gregory Korostishevsky as Andrei

Jane Curtin as Marjorie

Stephen Spinella as Paul

Christian Navarro as Kurt

Pun Bandhu as Agent Doyle

Erik LaRay Harvey as Agent Solanas

Brandon Scott Jones as Glen

Shae D'Lyn as Nell

Rosal Colon as Rachel

Anna Deavere Smith as Elaine

Marc Evan Jackson as Lloyd

Marcella Lowery as Guest at Party

Roberta Wallach as Tom Clancy Groupie

Tina Benko as Karen

Sandy Rosenberg as Yale Librarian

Kevin Carolan as Tom Clancy

Ben Rauch as Coat Check Guy

Ethel Fisher as Mrs. Unger

Chris Lamberth as Exterminator

Joanna Adler as Arlene

Mary B. McCann as Judge

Michael Laurence as Fenwick

Michael Cyril Creighton as Harry

Alice Kremelberg as Server

Moisés Acevedo as Stationery Clerk

Lucy DeVito as Gossipy Office Worker

Josh Evans as Boss in Office

Ricky Garcia as Security Guard

Charlotte Mary Wen as Cubicle Worker

Marcus Choi as Another Cubicle Worker

Justin Vivian Bond as Lounge Singer

Tim Cummings as Craig

Havilah Brewster as Toni

Dann Fink as Male (voice)

Zabryna Guevara as Female (voice)

Bonita Hamilton as Female (voice)

Dan McCabe as Male (voice)

Sean Oliver as Male (voice)

Lori Prince as Female (voice)

Armando Riesco as Male (voice)

Sandy Rustin as Female (voice)

George Aloi as Literary Agent (uncredited)

Tiffany Blair as Lady with Bird (uncredited)

Linwood Brown as Prosecutor (uncredited)

Kevin Cristaldi as Other Dealer (uncredited)

Barbara Ann Davison as Bookstore Employee (uncredited)

Peter Donovan as Greg (uncredited)

Antoine Drye as Musician in Bar Scene (uncredited)

Liz Eng as Lisa (uncredited)

George R. Golden as Bookshop Browser (uncredited)

Anne Hollister as Young Girl at Vet (uncredited)

Katie Kocik as Bookstore Customer (uncredited)

Ron Maestri as Book Store Customer (uncredited)

Doris McCarthy as Dinner Guest (uncredited)

Wayne J. Miller as Pancake Man at Counter (uncredited)

Bill Walters as Homeless Man (uncredited)