Jon Voight as Alfred Kroeber

Graham Greene as Ishi

David Ogden Stiers as Dr. Saxton Pope

Jack Blessing as Tom Waterman

Anne Archer as Henriette Kroeber

Daniel Benzali as Mr. Whitney

Christianne Hauber as Miss Edna Block

Charles Martinet as Assistant Museum Director

Carl D. Parker as Sheriff Weber

Angela Paton as Mrs. Gustafson

Benne Alder as Mrs. Whatley

Marie Bain as Nurse

Loryn Barlese as Ishi's Young Sister

Gilbert Bear as Ishi's Father

Lance Brady as Reporter #4

Roy Conrad as Reporter #2

Kevin Goetz as Medical Student

Neva Hutchinson as Mrs. Berney

John Ickes as Museum Director (as John Z. Ickes)

Trudy Kinerson as Ishi's Sister

Beverly LaBeau as Ishi's Mother

Stephen Lofaro as Doctor

George Maguire as Mr. Whatley

Edward Markmann as Photographer

Wanda McCaddon as Woman with Hat

Sean David McClelland as Reporter #3

C.W. Morgan as Rudy

James O'Connell as Wester Union Operator

John Olson as Museum Goer

Stephen Pocock as Bob

Christopher Pray as Reporter #1 (as Chris Pray)

Victor Preston as Ishi's Uncle

Nick Scoggin as Alcott

Toby Stump as Young Ishi

Brian VanDerWilt as Student

Anthony Snow as Museum Patron (uncredited)

Kerry van der Griend as Bicycle Rider (uncredited)