William Powell as Clarence Day Sr.

Irene Dunne as Vinnie Day

Elizabeth Taylor as Mary Skinner

Edmund Gwenn as Rev. Dr. Lloyd

Zasu Pitts as Cousin Cora Cartwright

Jimmy Lydon as Clarence Day Jr.

Emma Dunn as Margaret

Moroni Olsen as Dr. Humphries

Elisabeth Risdon as Mrs. Whitehead

Derek Scott as Harlan Day

Johnny Calkins as Whitney Benjamin Day

Martin Milner as John Day

Heather Wilde as Annie

Monte Blue as The Policeman

Mary Field as Nora

Clara Blandick as Miss Wiggins

Arlene Dahl as Girl at Delmonico's (uncredited)

Creighton Hale as Mr. Wickersham the Father of Twin Boys (uncredited)

Dick Gordon as Waiter at Delmonico's (uncredited)