Kumail Nanjiani as Kumail Nanjiani

Zoe Kazan as Emily Gardner

Holly Hunter as Beth Gardner

Ray Romano as Terry Gardner

Anupam Kher as Azmat Nanjiani

Zenobia Shroff as Sharmeen Nanjiani

Adeel Akhtar as Naveed Nanjiani

Bo Burnham as CJ

Aidy Bryant as Mary

Kurt Braunohler as Chris

Vella Lovell as Khadija

Myra Lucretia Taylor as Nurse Judy

Jeremy Shamos as Bob Dalavan

David Alan Grier as Andy Dodd

Ed Herbstman as Sam Highsmith

Shenaz Treasury as Fatima Nanjiani

Rebecca Naomi Jones as Jesse

Kuhoo Verma as Zubeida

Mitra Jouhari as Yazmin

Celeste Arias as Denise

Shana Solomon as Nurse Bette

Jeff Blumenkrantz as Dr. Wright

Linda Emond as Dr. Cunningham

Holly Chou as Dr. Whelan

Andrew Pang as Dr. Spellman

Alison Cimmet as Dr. Platt

Lawrence Ballard as Dr. Lewin

Shunori Ramanathan as Sumera

Spencer House as Racist Heckler

Susham Bedi as Tina (Khadija's Mother)

Rahul Bedi as Farhan (Khadija's Father)

Matthew Cardarople as Fast Food Cashier

Myra Turley as Waiting Room Person 1

William Stephenson as Waiting Room Person 2

Marilyn Torres as Waiting Room Person 3

Kerry Flanagan as Waiting Room Person 4

Jack O'Connell as Waiting Room Person 5

Charles Gould as Waiting Room Person 6

Isabel Shill as Party Goer 1

Lauren Patten as Party Goer 2

Keilly McQuail as Party Goer 3

Zach Cherry as Party Goer 4

Sophia Muller as Chrissy (uncredited)

Jack Corrigan as Restaurant Boy (uncredited)