Dudley Moore as Rob Salinger

Amy Irving as Maude Salinger

Ann Reinking as Micki Salinger

Richard Mulligan as Leo Brody

George Gaynes as Dr. Eugene Glztszki

Wallace Shawn as Dr. Elliot Fibel

John Pleshette as Hap Ludlow

H.B. Haggerty as Barkhas Guillory

Lu Leonard as Nurse Mary Verbeck

Priscilla Pointer as Diana Hutchison

Robert Symonds as Ezra Hutchison

George Coe as Governor Lanford

Gustav Vintas as Dr. Kondoleon

Ken Olfson as Interior Decorator

Philippe Denham as TV Cameraman

Emma Walton Hamilton as Maude's Nurse

Ruth Silveira as Micki's Nurse

Jack 'Wildman' Armstrong as Self

André Roussimoff as Self

John Minton as Self

Luke Scarpa as Self

John J. Flynn Jr. as Madman O'Rourke

Gene LeBell as Wrestling Referee

Wiley Harker as Oliver Cushing III

Tina Theberge as Maid of Honor

Jim Giggins as Newscaster

Roger Rose as Newscaster

Tiiu Leek as Newscaster

Jamie Abbott as Frank Lanford

Christa Denton as Alice Lanford

Robby Kiger as Ehren Lanford

Paul Bright as Teenager on Bike

Robert Nadder as Geologist

Hanna Landy as Admissions Clerk

Billy Beck as Finn

Lou Felder as Sales Clerk

Virginia Kiser as Mrs. Lanford

Jerry Martin as Security Guard

Gerry Gibson as Ben Sitkowitz

Edith Fields as Valerie Sitkowitz

Arthur Lessac as Bailiff

Ed Call as Campaign Manager